Uzbekistan has signed trade agreements with 47 countries providing most favored nation treatment. It has also signed bilateral investment treaties with 52 countries, but four of them have not entered into force and two have expired. The country became an observer in the Eurasian Economic Union (EAEU) in 2020 and joined the Eurasian Development Bank in 2025, becoming its third largest shareholder, with 10 percent share in capital. In June 2025 the Board of Governors of the New Development Bank of BRICS approved Uzbekistan’s accession. Uzbekistan is not a member of the World Trade Organization (WTO) but is actively working on accession. As of August 2025, it completed negotiations with 25 WTO member countries. In 2004, Uzbekistan and Russia signed a Strategic Framework Agreement that also included free trade and investment concessions. 

In 2005, the government signed the “Treaty of Alliance Relations” with Russia, with provisions for economic cooperation. Uzbekistan and Ukraine’s 2004 agreement removed all bilateral trade barriers. Uzbekistan’s membership in the CIS Free Trade Zone was formalized in 2014.  Uzbekistan currently has free trade agreements with ten countries - all of them are former members of the Soviet Union. In 2023, CIS countries signed an Agreement on the free trade of services and investments. In 2021, the European Union accepted Uzbekistan as the ninth beneficiary of its expanded General System of Preferences (GSP+) trade arrangement, which removes tariffs on two thirds (6,200 titles) of the product lines covered by GSP. On July 6, 2022, the European Union and Uzbekistan completed negotiations for a new Enhanced Partnership and Cooperation Agreement, and the chief negotiators initialed it. 

In 2021, Uzbekistan became the first country admitted to the United Kingdom’s Enhanced Framework Generalized Scheme of Preferences, which allows zero import duty on more than 7,800 products made in Uzbekistan. In  2023, Uzbekistan approved a preferential trade agreement with Turkiye covering 12 items for each side – mostly agricultural products of Uzbekistan and industrial products of Turkiye. Uzbekistan signed preferential trade agreements also with Pakistan and Iran in 2023, and with Afghanistan in 2024. The “Treaty between the Government of the Republic of Uzbekistan and the Government of the United States of America Concerning the Encouragement and Reciprocal Protection of Investment” was signed in Washington, D.C., on December 16, 1994, and ratified soon thereafter by the Uzbek Parliament.  The U.S. government, however, has not acted to bring this agreement into force. In 2004, Uzbekistan signed the regional Trade Investment Framework Agreement (TIFA) with the U.S. Trade Representative’s Office and four of its Central Asian neighbors – Tajikistan, Turkmenistan, Kazakhstan, and the Kyrgyz Republic.